What does this research mean for the field?

Intracellular chloride in sheep cardiac Purkinje fibres is actively accumulated above passive equilibrium via a sodium-independent, DIDS-sensitive chloride-bicarbonate exchange mechanism. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 1986The Journal of PhysiologyOpen Access

An investigation of chloride‐bicarbonate exchange in the sheep cardiac Purkinje fibre.

View Full Paper

Ask AI

Bookmark

Population

Isolated sheep cardiac Purkinje fibres

Comparison

Manipulation of external chloride, bicarbonate… vs Baseline or control conditions

Design

Preclinical

Authors

RVRichard D. Vaughan‐JonesElectrophysiology

Discussion

Member takes

Implication

Challenges passive Cl equilibrium predictions in Purkinje fibres; extends cardiac ion-transport models beyond constant-field theory.

Structured PICO

Population

Isolated sheep cardiac Purkinje fibres

Intervention

Manipulation of external chloride, bicarbonate, and pH, and application of inhibitors (DIDS, amiloride, piretanide)

Comparator

Baseline or control conditions

Outcome

Intracellular Cl activity (aiCl) and intracellular pH (pHi)surrogate

This preclinical study characterizes a chloride-bicarbonate exchange mechanism in sheep cardiac Purkinje fibres that regulates intracellular chloride and pH.

Cite This Study

Richard D. Vaughan‐Jones (1986) studied this question.

synapsesocial.com/papers/6a1bf8811567d2fc4d5f592c https://doi.org/10.1113/jphysiol.1986.sp016259

View Full Paper

Ask AI

Bookmark

An investigation of chloride‐bicarbonate exchange in the sheep cardiac Purkinje fibre.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

An investigation of chloride‐bicarbonate exchange in the sheep cardiac Purkinje fibre.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider