October 1, 1979The Journal of PhysiologyOpen Access

Regulation of chloride in quiescent sheep‐heart Purkinje fibres studied using intracellular chloride and pH‐sensitive micro‐electrodes.

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Population

Quiescent sheep cardiac Purkinje fibres

Comparison

Manipulation of external chloride… vs Normal Tyrode solution

Design

Preclinical

Authors

RVRichard D. Vaughan‐JonesElectrophysiology

Discussion

Member takes

Implication

Demonstrates reversible Cl/HCO3 exchange in sheep Purkinje fibres; leaves open its role in human cardiac pHi regulation.

Structured PICO

Population

Quiescent sheep cardiac Purkinje fibres

Intervention

Manipulation of external chloride, bicarbonate/CO2, temperature, potassium, and application of SITS (4-acetamido-4'-isothiocyanato-stilbene-2,2'-disulphonic acid)

Comparator

Normal Tyrode solution (pH 7.40, buffered with approximately 22 mM-bicarbonate/approximately 5% CO2 + 95% O2)

Outcome

Intracellular chloride activity (alpha iCl) and intracellular pH (pHi)surrogate

A Cl/HCO3 exchange mechanism operates reversibly across the membrane of quiescent sheep Purkinje fibres, contributing to high resting intracellular chloride levels.

Cite This Study

Richard D. Vaughan‐Jones (1979) studied this question.

synapsesocial.com/papers/6a70a4c45d37378ac1ddc697 https://doi.org/10.1113/jphysiol.1979.sp012957

View Full Paper

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Regulation of chloride in quiescent sheep‐heart Purkinje fibres studied using intracellular chloride and pH‐sensitive micro‐electrodes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of chloride in quiescent sheep‐heart Purkinje fibres studied using intracellular chloride and pH‐sensitive micro‐electrodes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider