Key result
A computationally efficient 3-variable phenomenological model of ventricular tissue accurately reproduced the transmural heterogeneity and electrocardiographic patterns of Brugada syndrome.
A highly computationally efficient 3-variable phenomenological model accurately reproduces transmural heterogeneity and ECG patterns in healthy and Brugada syndrome conditions.
Does not support clinical use; leaves open further validation of computational Brugada models.
We present a transmurally heterogeneous phe-nomenological model of ventricular tissue that is designed to reproduce the most important features of action potential prop-agation of endocardial, midmyocardial, and epicardial tissue. Our model consists of only 3 variables and 20 parameters. Therefore, it is highly computational efficient and easy to fit to experimental data. We exploited our myocyte model to simulate action potential propagation in a 3D slab of cardiac tissue both in healthy conditions and in presence of Brugada syndrome. The results show that our model can accurately reproduce the transmural heterogeneity of the ventricular wall and the main characteristics of electrocardiographic pattern both in healthy and pathological conditions.
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Biasi et al. (2022) studied Brugada Syndrome. Transmurally heterogeneous phenomenological model vs. Healthy conditions was evaluated. A computationally efficient 3-variable phenomenological model of ventricular tissue accurately reproduced the transmural heterogeneity and electrocardiographic patterns of Brugada syndrome.
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