Key result
High-spatial resolution contrast-enhanced MRI successfully visualized the three-dimensional branching laminar architecture of ex vivo rat hearts, showing significant correlation with histology (r0=0.35, P<10^-5).
Why the study?
Can high-spatial resolution contrast-enhanced MRI visualize and quantify the laminar architecture of ex vivo rat hearts comparably to histology?
Can high-spatial resolution contrast-enhanced MRI visualize and quantify the laminar architecture of ex vivo rat hearts comparably to histology?
Effect estimate: r0 0.35
p-value: p=<10^-5
High-spatial resolution contrast-enhanced MRI can accurately visualize and quantify the complex, branching 3D laminar architecture of the whole rat heart, providing results comparable to traditional histology.
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Supports ex vivo rat heart imaging; leaves open translation to in vivo or human use.
Gilbert et al. (2011) studied Healthy (n=4). High-spatial resolution contrast-enhanced MRI vs. Histology was evaluated on Correlation of in-plane sheet angles between MRI and histology (r0 0.35, p=<10^-5). High-spatial resolution contrast-enhanced MRI successfully visualized the three-dimensional branching laminar architecture of ex vivo rat hearts, showing significant correlation with histology (r0=0.35, P<10^-5).
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