Key result
3D histology processing shrinks rabbit heart anatomical volume ~37% versus MRI.
High-resolution serial histology combined with MRI allows quantitative differentiation of cell types in whole-heart datasets, though significant tissue shrinkage occurs during processing.
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Tissue shrinkage requires volume correction in histology-MRI fusion; leaves open refined protocols for whole-heart cell mapping in animal models.
Burton et al. (2014) studied this question. Three-dimensional histology and MRI segmentation techniques vs. Magnetic resonance imaging (MRI) was evaluated on Anatomical and morphological volume shrinkage. Three-dimensional histology processing of rabbit hearts resulted in a 37.2% reduction in anatomical volume and a 48% decrease in morphological volume compared to magnetic resonance imaging.
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