Why the study?
Quantifying pathological cardiomyocyte hypertrophy and capillary rarefaction in cardiac histology is technically challenging and highly time-consuming.
Population
Transverse aortic constriction mouse models and autopsy samples from patients with and without aortic stenosis
Comparison
HeartJ semiautomated quantification pipeline vs manual methods
Design
Preclinical and clinical histological validation study
Authors
Loading...
Confirms translational relevance of murine hypertrophy models; leaves open prospective validation of HeartJ in clinical cohorts.
HeartJ provides a freely available, semiautomated pipeline for rapid and objective quantitative histological analysis of cardiomyocyte hypertrophy and capillary density in preclinical and clinical samples.
Droste et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: