What does this research mean for the field?

Men with low HDL cholesterol levels, regardless of triglyceride levels, exhibit significantly lower postheparin lipoprotein lipase (LPL) activity and higher hepatic triglyceride lipase (HTGL) activity compared to normolipidemic men. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the correlation between lipolytic enzyme activities and HDL cholesterol levels in subjects with low HDL levels.

August 1, 1993Arteriosclerosis and Thrombosis A Journal of Vascular BiologyOpen Access

Activities of lipoprotein lipase and hepatic triglyceride lipase in postheparin plasma of patients with low concentrations of HDL cholesterol.

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Why the study?

Are postheparin plasma activities of LPL and HTGL altered in male subjects with low HDL-C levels compared to normolipidemic controls?

Population

290 male subjects, comprising 159 with low HDL-C and normal triglycerides, 80 with low HDL-C and elevated…

Design

Cross-sectional

Authors

BBBarbara BladesNew South Wales Department of Primary Industries GVGloria Lena VegaPreventive Cardiology SGS M GrundyNational Institutes of Health

Discussion

Member takes

Implication

Low HDL-C associates with lower LPL and higher HTGL activities in men; leaves open causal roles or therapeutic targets.

Key Points

To investigate the correlation between lipolytic enzyme activities and HDL cholesterol levels in subjects with low HDL levels.
Analyzed postheparin plasma activities of LPL and HTGL in two low-HDL groups and a normal-HDL group.
Included 159 male subjects with low HDL-C and normal triglyceride levels, and 80 male subjects with low HDL-C and elevated triglyceride levels.
Compared enzyme activities across groups to identify significant differences.
LPL activities were significantly lower in both low-HDL groups (9.9 and 10.4 mmol/h/L) compared to the normal-HDL group (12.5 mmol/h/L), P < .001.
HTGL activities were higher in the low-HDL groups (39.3 and 44.4 mmol/h/L) than normal-HDL (29.7 mmol/h/L), P < .001.
Mean LPL/HTGL ratios were significantly lower in the low-HDL groups compared to the normal-HDL group.

Structured PICO

Are postheparin plasma activities of LPL and HTGL altered in male subjects with low HDL-C levels compared to normolipidemic controls?

Population

290 male subjects, comprising 159 with low HDL-C (< 40 mg/dL) and normal triglycerides (< 250 mg/dL), 80 with low HDL-C (< 40 mg/dL) and elevated triglycerides (≥ 250 mg/dL), and 51 normolipidemic controls.

Comparator

51 normolipidemic (normal-HDL) male subjects

Outcome

Postheparin plasma activities of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL)surrogate

Low HDL-C levels in men, regardless of triglyceride levels, are associated with decreased lipoprotein lipase and increased hepatic triglyceride lipase activities.

Cite This Study

Blades et al. (1993) studied this question.

synapsesocial.com/papers/6a1bfda726cb5670aa9d387e https://doi.org/10.1161/01.atv.13.8.1227

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