Why the study?
Does familial hepatic lipase deficiency alter lipoprotein profiles compared to unaffected family members?
Population
Extended pedigree with familial hepatic lipase deficiency, including 3 affected brothers, 1 affected child…
Design
Cross-sectional
Authors
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Suggests LDL/HDL triglyceride enrichment as a feature of familial hepatic lipase deficiency; leaves open contributions from additional genes to hyperlipidemia.
Does familial hepatic lipase deficiency alter lipoprotein profiles compared to unaffected family members?
Familial hepatic lipase deficiency is characterized by triglyceride enrichment of LDL and HDL, though additional independent genes may contribute to hyperlipidemia in affected pedigrees.
Connelly et al. (1990) studied this question.
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