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What are the effects of clinically relevant concentrations of anesthetics, sedatives, and opioids on ventilatory control?
What are the effects of clinically relevant concentrations of anesthetics, sedatives, and opioids on ventilatory control?
This review summarizes the current understanding of how clinically relevant doses of anesthetics and opioids affect ventilatory control in humans and mammals.
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Clinicians should monitor ventilatory depression closely with standard anesthetics and opioids; leaves open validation in diverse perioperative populations.
This article provides a comprehensive, up to date summary of the effects of volatile, gaseous, and intravenous anesthetics and opioid agonists on ventilatory control. Emphasis is placed on data from human studies. Further mechanistic insights are provided by in vivo and in vitro data from other mammalian species. The focus is on the effects of clinically relevant agonist concentrations and studies using pharmacological, that is, supraclinical agonist concentrations are de‐emphasized or excluded.
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Stuth et al. (2012) studied this question.
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