Key result
Multiphoton microscopy revealed that action potential rise times were significantly slower in the infarct zone (9.13 ms) compared to the normal zone (2.23 ms) in rat hearts post-myocardial infarction.
Population
Male Wistar rats with an apical infarct induced in the left ventricle by permanent ligation of the left…
Comparison
Optical mapping using di-4-ANEPPS and Fura-2/AM… vs Comparison between normal zone, border zone, and…
Design
Preclinical
Follow-up
4-5 weeks
Authors
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Hypothesis-generating in rat MI models; leaves open human translation and arrhythmogenic mechanisms.
Absolute Event Rate: 9.13% vs 2.23%
p-value: p=<0.001
Multiphoton microscopy reveals that post-MI scar tissue contains discrete layers with entrained electrical activity but altered electrophysiology and no calcium transients, suggesting complex structural-functional remodeling.
Ghouri et al. (2018) studied Myocardial Infarction (n=16). Optical mapping using multiphoton microscopy vs. Normal zone myocardium was evaluated on Action potential rise time (10-90% upstroke) (p=<0.001). Multiphoton microscopy revealed that action potential rise times were significantly slower in the infarct zone (9.13 ms) compared to the normal zone (2.23 ms) in rat hearts post-myocardial infarction.
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