Key result
Intramural electrical mapping in the peri-infarct region of chronic MI revealed significant focal activation delays (4-37 ms; P<0.0001) but no reduction in conduction velocity compared to controls.
Why the study?
Altered electrical behavior alongside healed myocardial infarcts increases sudden cardiac death risk, but the multidimensional mechanisms remain poorly understood.
Population
4 sheep 13 wk after antero-apical reperfusion infarction and 4 non-infarcted control sheep
Comparison
Infarcted peri-infarct region vs non-infarcted controls
Design
Preclinical experimental electrophysiological study
Follow-up
13 wk
Authors
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Focal activation delays without CV slowing in chronic MI peri-infarct zones suggest structural remodeling; leaves open relevance to human post-MI arrhythmia mechanisms.
p-value: p=< 0.0001
In a sheep model of chronic MI, intramural electrical mapping showed focal activation delays but preserved conduction velocity in the peri-infarct region, suggesting conduction abnormalities are predominantly structural.
Trew et al. (2019) studied Chronic reperfusion myocardial infarction (n=8). Intramural electrical mapping and multisite stimulation vs. Non-infarcted control sheep was evaluated on Intramural spread of electrical activation (activation delays and conduction velocity) (p=< 0.0001). Intramural electrical mapping in the peri-infarct region of chronic MI revealed significant focal activation delays (4-37 ms; P<0.0001) but no reduction in conduction velocity compared to controls.
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