Key result
Neither biventricular nor right ventricular pacing altered the reductions in action potential amplitudes, conduction velocities, and calcium transients caused by myocardial infarction.
Why the study?
Does the site of ventricular pacing alter the properties of electrical propagation and calcium signaling after myocardial infarction in a rabbit model?
Does the site of ventricular pacing alter the properties of electrical propagation and calcium signaling after myocardial infarction in a rabbit model?
In a rabbit model of myocardial infarction, biventricular pacing does not alter regional electrical conduction or calcium signaling properties, suggesting its benefits are mediated through other mechanisms.
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Does not support pacing site as modulator of post-MI conduction or calcium properties in rabbits; leaves open alternative mechanisms for biventricular pacing benefit.
Saba et al. (2007) studied Myocardial infarction (n=26). Right ventricular or biventricular pacing vs. Sham-operated or MI with no pacing was evaluated on Regional voltage and calcium signals and their propagation properties. Neither biventricular nor right ventricular pacing altered the reductions in action potential amplitudes, conduction velocities, and calcium transients caused by myocardial infarction.
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