Population
15 Langendorff-perfused rabbit hearts with myocardial infarction for 1 week
Comparison
Simultaneous optical mapping of intracellular… vs Sites remote from the infarct
Design
Preclinical
Authors
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Supports peri-infarct remodeling in VF maintenance in infarct models; leaves open translation to human therapies.
In a rabbit model of subacute myocardial infarction, dynamic action potential and calcium cycling remodelling in the peri-infarct zone contribute to the initiation and maintenance of ventricular fibrillation.
Chou et al. (2007) studied this question.
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