Key result
Carriers of a novel functional mutation of DDAH-1 had a significantly elevated risk for cardiovascular disease and a tendency to develop hypertension.
Why the study?
Are DDAH gene polymorphisms associated with increased cardiovascular risk?
Population
16 men with either low or high plasma asymmetric dimethylarginine (ADMA) concentrations
Design
Review
Authors
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DDAH-1 mutations may increase cardiovascular susceptibility; hypothesis-generating and requires prospective validation before clinical adoption.
Observational (n=16)
Are DDAH gene polymorphisms associated with increased cardiovascular risk?
DDAH-1 mutations may play a clinical role in ADMA metabolism and increase susceptibility to cardiovascular disease and hypertension.
Valkonen et al. (2005) conducted an observational in Cardiovascular disease risk (n=16). DDAH-1 mutation vs. Non-carriers was evaluated on Cardiovascular disease and hypertension. Carriers of a novel functional mutation of DDAH-1 had a significantly elevated risk for cardiovascular disease and a tendency to develop hypertension.
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