What question did this study set out to answer?

To determine the biological effects and molecular signaling mechanisms by which vascular endothelial growth factor-B (VEGF-B) influences coronary vasculature, cardiac metabolism, and ischemic injury.

January 21, 2014EMBO Molecular MedicineOpen Access

VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

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To determine the biological effects and molecular signaling mechanisms by which vascular endothelial growth factor-B (VEGF-B) influences coronary vasculature, cardiac metabolism, and ischemic injury.
Engineered cardiomyocyte-specific VEGF-B gain-of-function transgenic, gene-targeted loss-of-function, and wild-type rodent models.
Evaluated ischemic resistance, mitochondrial complex I activity during ischemia-reperfusion, fatty acid uptake, and signaling through VEGFR2, Erk1/2, Akt, mTORC1, and AMPK pathways.
Analyzed VEGF-B expression patterns in human heart disease tissue specimens relative to healthy controls.
Transgenic VEGF-B stimulated coronary arterial expansion via VEGFR2 and Erk1/2 signaling while preserving mitochondrial complex I function and conferring protection against myocardial infarction.
Cardiomyocyte metabolism was reprogrammed toward glucose oxidation and macromolecular synthesis through Akt/mTORC1 activation and AMPK downregulation, without altering myocardial fatty acid uptake.
VEGF-B expression was significantly reduced in diseased human myocardium compared with non-diseased tissue.

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Implication

Preclinical study demonstrates that VEGF-B expands coronary vessels and reprograms metabolism in rodent hearts, suggesting a therapeutic strategy for ischemic heart disease.

Cite This Study

Kivelä et al. (2014) studied this question.

synapsesocial.com/papers/6a1c076526cb5670aa9d468a https://doi.org/10.1002/emmm.201303147

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Implication

Preclinical study demonstrates that VEGF-B expands coronary vessels and reprograms metabolism in rodent hearts, suggesting a therapeutic strategy for ischemic heart disease.

VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Key Points

Discussion

Implication

Cite This Study

VEGF‐B‐induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Key Points

Discussion

Implication

Cite This Study

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