Why the study?
Does VEGF-B overexpression induce angiogenesis, vascular leak, inflammation, or coronary vessel growth in mice and rats?
Population
Mice and rats
Design
Preclinical
Authors
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Supports selective coronary growth by VEGF-B in rats without leak or inflammation; leaves open therapeutic translation to human ischemic disease.
Does VEGF-B overexpression induce angiogenesis, vascular leak, inflammation, or coronary vessel growth in mice and rats?
VEGF-B acts as a coronary growth factor in rats, increasing arterial supply to the subendocardial myocardium without inducing vascular leak or inflammation, suggesting therapeutic potential for ischemic heart disease.
Bry et al. (2010) studied this question.
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