What does this research mean for the field?

Q: What does this research mean for the field?

Baseline plasma levels of thromboxane A2 on admission are an independent predictor of coronary no-reflow following primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 10, 2008European Heart Journal

Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention

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Why the study?

Are admission plasma levels of thromboxane A2 associated with no-reflow after primary percutaneous coronary intervention in patients with first STEMI?

Structured PICO

Are admission plasma levels of thromboxane A2 associated with no-reflow after primary percutaneous coronary intervention in patients with first STEMI?

Population

47 consecutive patients admitted for a first ST-segment elevation myocardial infarction (STEMI) and undergoing primary percutaneous coronary intervention (PPCI) within 12 hours of symptom onset, mean age 62.5 +/- 12.7, 76.6% male.

Intervention

Admission plasma levels of Thromboxane A2 (TXA2)

Outcome

Angiographic no-reflow (final TIMI flow ≤2 or final TIMI flow 3 with a myocardial blush grade of <2) and lack of ST-segment resolution (≤50% from baseline)surrogate

Higher admission plasma levels of thromboxane A2 are independently associated with an increased risk of angiographic and electrocardiographic no-reflow after primary PCI for STEMI.

Discussion

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Implication

May aid no-reflow risk stratification after STEMI PCI; leaves open whether TXA2 modulation improves outcomes.

Cite This Study

Niccoli et al. (2008) studied this question.

synapsesocial.com/papers/6a1c07e61567d2fc4d5f77cc https://doi.org/10.1093/eurheartj/ehn325

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Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention

Structured PICO

Discussion

Implication

Cite This Study

Plasma levels of thromboxane A2 on admission are associated with no-reflow after primary percutaneous coronary intervention

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider