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May 1, 1998Cardiovascular ResearchOpen Access

Disparate effects of adhesion and degranulation of platelets on myocardial and coronary function in postischaemic hearts

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Population

Isolated guinea pig hearts subjected to ischaemia and reperfusion

Comparison

Infusion of a bolus of 10^8 washed human… vs Tyrode's solution (control group)

Design

Preclinical

Follow-up

15 minutes of reperfusion

Authors

BHBernhard HeindlLMU KlinikumSZStefan ZahlerHokkaido Pharmaceutical UniversityUWUlrich WelschAlfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung

Discussion

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Implication

Platelet infusion impairs post-ischemic recovery in this animal model; leaves open net platelet effects during human ischemia-reperfusion.

Structured PICO

P
Population
Isolated guinea pig hearts subjected to ischaemia (20 min of low-flow perfusion and 10 min of global ischaemia) and reperfusion
I
Intervention
Infusion of a bolus of 10^8 washed human platelets +/- lamifiban, supernatant of 10^8 thrombin-stimulated platelets, fibrinogen (2 microM), or lamifiban (2 microM) during low-flow perfusion
C
Comparator
Tyrode's solution (control group)
O
Outcome
Recovery of external heart work (EHW) determined pre- and postischaemicallysurrogate

Platelet adhesion to the coronary endothelium during myocardial ischaemia impairs cardiac recovery, whereas platelet-released constituents like fibrinogen may beneficially reduce coronary permeability.

Cite This Study

Heindl et al. (1998) studied this question.

synapsesocial.com/papers/6a792bd32eb3c7e469f36780https://doi.org/10.1016/s0008-6363(98)00032-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric oxide and prostacyclin modulate the alterations in cardiac action potential duration mediated by platelets during ischaemia1995 · 41 citations
  2. 2Functional coronary microvascular injury evident as increased permeability due to brief ischemia and reperfusion.1990 · 148 citations
  3. 3Effect of acute edema on left ventricular function and coronary vascular resistance in the isolated rat heart1994 · 76 citations
  4. 4Examination of the roles of glycoprotein Ib and glycoprotein IIb/IIIa in platelet deposition on an artificial surface using clinical antiplatelet agents and monoclonal antibody blockade1991 · 51 citations
  5. 5Human endothelial cells express integrin receptors on the luminal aspect of their membrane1992 · 134 citations