April 1, 1995Cardiovascular Research

Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia

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Population

Isolated buffer perfused guinea pig hearts performing pressure-volume work under standardised conditions…

Comparison

Constant flow reperfusion in the presence of… vs Reperfusion with Krebs-Henseleit buffer only

Design

Preclinical

Follow-up

35 minutes of reperfusion

Authors

PRP. RaschkeKlinikum rechts der Isar BBB.F. BeckerLudwig-Maximilians-Universität München

Discussion

Member takes

Implication

Neutrophils impair post-ischemic recovery via A1/PAF pathways in this model; leaves open whether antagonists offer clinical cardioprotection.

Structured PICO

Population

Isolated buffer perfused guinea pig hearts performing pressure-volume work under standardised conditions subjected to 15 min of global ischaemia

Intervention

Constant flow reperfusion (5 ml.min-1) in the presence of homologous neutrophils (approximately 2000 cells.microliters-1 perfusate), with or without adenosine A1 receptor antagonist (dipropyl-8-cyclopentyl-xanthine), A2 antagonist (3,7-dimethyl-1-propargyl-xanthine), or PAF receptor antagonist (WEB 2086)

Comparator

Reperfusion with Krebs-Henseleit buffer only (absence of neutrophils)

Outcome

Recovery of postischaemic heart function (external heart work) assessed 20 min after resuming worksurrogate

Neutrophils exacerbate myocardial reperfusion injury even after brief ischaemia, a process mediated by adenosine A1 receptors and platelet activating factor.

Cite This Study

Raschke et al. (1995) studied this question.

synapsesocial.com/papers/6a7df530432a20ae7c150fa0 https://doi.org/10.1016/s0008-6363(96)88536-1

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Implication

Neutrophils impair post-ischemic recovery via A1/PAF pathways in this model; leaves open whether antagonists offer clinical cardioprotection.

Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine and PAF dependent mechanisms lead to myocardial reperfusion injury by neutrophils after brief ischaemia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider