Why the study?
Do PAF antagonists reduce arrhythmias and platelet activation in a greyhound model of acute myocardial ischaemia and reperfusion?
Population
Anaesthetized open-chest greyhounds subjected to 40 min of coronary artery occlusion followed by reperfusion
Comparison
Pretreatment with PAF antagonists BN52021 or… vs Controls
Design
Preclinical
Follow-up
40 min of occlusion followed by reperfusion
Authors
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Does not change clinical practice; leaves open a role for PAF in human ischemia-reperfusion arrhythmias.
Do PAF antagonists reduce arrhythmias and platelet activation in a greyhound model of acute myocardial ischaemia and reperfusion?
PAF antagonists attenuate ischemia and reperfusion-induced arrhythmias and platelet activation in an experimental greyhound model, suggesting a role for PAF in these processes.
Wainwright et al. (1989) studied this question.
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