May 1, 2004British Journal of PharmacologyOpen Access

Left regional cardiac perfusion in vitro with platelet‐activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous ‘mediators’ facilitated by interactions, and moderated by paradoxical antagonism

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Why the study?

Does Platelet-activating factor (PAF) and its interaction with norepinephrine and K+ induce ventricular arrhythmias in rat isolated hearts?

Population

Rat isolated hearts (ischaemia-free in vitro heart bioassay)

Design

Preclinical

Authors

KBKathryn E BakerCardiff University MCMichael J. CurtisElectrophysiology

Discussion

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Implication

PAF arrhythmogenicity in isolated hearts may not translate to humans; leaves open whether selective blockade prevents clinical VF.

Structured PICO

Does Platelet-activating factor (PAF) and its interaction with norepinephrine and K+ induce ventricular arrhythmias in rat isolated hearts?

Population

Rat isolated hearts (ischaemia-free in vitro heart bioassay)

Intervention

Platelet-activating factor (PAF) (0.1-100 nmol) administered selectively to the left coronary bed, alone or with norepinephrine (0.1 microm) and/or K+ (8 and 15 mm), or PAF antagonist BN-50739 (10 microm)

Outcome

Ventricular arrhythmias, QT interval, and coronary flowsurrogate

PAF contributes to arrhythmogenesis, but its complex interactions with other ischaemic mediators suggest that selectively blocking PAF alone is unlikely to prevent ventricular fibrillation or sudden cardiac death.

Cite This Study

Baker et al. (2004) studied this question.

synapsesocial.com/papers/6a8bcd31634d203318b20af2 https://doi.org/10.1038/sj.bjp.0705767

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Left regional cardiac perfusion in vitro with platelet‐activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous ‘mediators’ facilitated by interactions, and moderated by paradoxical antagonism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Left regional cardiac perfusion in vitro with platelet‐activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous ‘mediators’ facilitated by interactions, and moderated by paradoxical antagonism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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