Population
Ischemic-isolated rabbit hearts and nonischemic rabbit hearts perfused with or without autologous rabbit…
Comparison
Pretreatment of autologous rabbit platelets with… vs Reperfusion without platelets, or platelets…
Design
Preclinical
Authors
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PAF antagonism mitigates reperfusion injury in rabbits; leaves open clinical translation to human ischemia-reperfusion.
Platelet-activating factor released during ischemia-reperfusion mediates cardiac dysfunction via platelet activation, which can be prevented by PAF receptor antagonism in a rabbit model.
Montrucchio et al. (1989) studied this question.
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