Key result
Oral PAF-receptor antagonist L-652,731 prolongs rabbit bleeding time, indicating PAF mediates platelet plug formation.
Why the study?
The physiological role of platelet-activating factor (PAF) in primary hemostasis in rabbits was not established.
Population
Rabbits
Comparison
PAF-receptor antagonist L-652,731 vs baseline
Design
Experimental study measuring skin bleeding times after oral antagonist administration
Follow-up
1 hour after administration
Authors
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PAF may contribute to hemostasis; leaves open bleeding risk with antagonists in humans.
Livio et al. (1988) studied Primary hemostasis. L-652,731 (PAF-receptor antagonist) vs. Baseline (before administration) was evaluated on Skin bleeding time. Oral administration of the PAF-receptor antagonist L-652,731 significantly prolonged skin bleeding time in rabbits, suggesting locally released PAF plays a physiological role in platelet plug formation.
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