September 1, 1991British Journal of PharmacologyOpen Access

Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung

View Full Paper

Ask AI

Bookmark

Population

Rabbit isolated lungs perfused via the pulmonary artery with Tyrode solution

Comparison

Infusion of platelet activating factor vs Control infusions, lyso-PAF, or PAF in the…

Design

Preclinical

Follow-up

60 min per experiment

Authors

JSJ. Paul SealeAugusta University SNSussan NoursharghQueen Mary University of London PHPaul G. HellewellBrunel University of London

Discussion

Member takes

Implication

PAF antagonism attenuates experimental pulmonary leakage; leaves open translation to human microvascular injury.

Structured PICO

Population

Rabbit isolated lungs perfused via the pulmonary artery with Tyrode solution

Intervention

Infusion of platelet activating factor (PAF) (3 nmol min-1 for 10 min or 1 nmol bolus)

Comparator

Control infusions, lyso-PAF, or PAF in the presence of antagonists (L-652731, indomethacin, dazmegrel, BW 755C)

Outcome

Microvascular 125I-albumin leakage and perfusion pressuresurrogate

PAF acts as a vasoconstrictor and induces protein accumulation in the rabbit pulmonary circulation via receptor-mediated mechanisms and cyclo-oxygenase pathways.

Cite This Study

Seale et al. (1991) studied this question.

synapsesocial.com/papers/6a93f05da908965a9a92c2cc https://doi.org/10.1111/j.1476-5381.1991.tb12415.x

View Full Paper

Ask AI

Bookmark

Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider