Why the study?
Does platelet-activating factor (PAF) increase pulmonary microvascular permeability and pulmonary arterial pressure in rats?
Population
Rats undergoing in vivo pulmonary arterial catheterization
Comparison
Platelet-activating factor administered… vs Baseline or unblocked state
Design
Preclinical
Authors
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Supports PAF-receptor blockade to limit permeability in experimental bacteremia; leaves open clinical translation to human sepsis.
Does platelet-activating factor (PAF) increase pulmonary microvascular permeability and pulmonary arterial pressure in rats?
Platelet-activating factor mediates pulmonary edema primarily by increasing microvascular permeability rather than by increasing pulmonary arterial pressure.
Clavijo et al. (2001) studied this question.
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