January 1, 1990AJP Gastrointestinal and Liver Physiology
Platelet-activating factor-induced microvascular dysfunction: role of adherent leukocytes
Population
Animal model (species not specified in abstract)
Comparison
Local intra-arterial infusions of… vs Baseline or animals not treated with MoAb IB4
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May implicate adherent leukocytes in PAF-induced intestinal capillary leak; human relevance and therapeutic targeting remain untested.
Structured PICO
P
Population
Animal model (species not specified in abstract)
I
Intervention
Local intra-arterial infusions of Platelet-activating factor (PAF) at 4, 20, and 40 ng/min, with or without monoclonal antibody MoAb IB4
C
Comparator
Baseline or animals not treated with MoAb IB4
O
Outcome
Intestinal transcapillary, lymphatic, and transmucosal water and protein fluxessurrogate
Platelet-activating factor promotes fluid and protein filtration across intestinal capillaries, a microvascular effect mediated in part by adherent leukocytes.
Cite This Study
Kubes et al. (1990) studied this question.