Key result
Transient coronary occlusion in pigs triggered platelet deposition and impaired coronary flow reserve and contractile function in distant cardiac regions, correlating with platelet activation.
Population
20 pigs (10 in series A, 10 in series B)
Design
Preclinical
Follow-up
After reflow/reperfusion
Authors
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Remote effects after transient occlusion in pigs; hypothesis-generating for platelet activation in human ischemia but should not change practice.
Transient coronary occlusion in a porcine model induces platelet deposition and functional impairment in remote, non-ischemic myocardium, driven by systemic platelet activation.
Barrabés et al. (2007) studied Transient coronary occlusion (n=20). 48-min coronary occlusion was evaluated on Platelet deposition, coronary flow reserve, and contractile function in remote cardiac regions. Transient coronary occlusion in pigs triggered platelet deposition and impaired coronary flow reserve and contractile function in distant cardiac regions, correlating with platelet activation.
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