What does this research mean for the field?

Labetalol is an effective combined alpha- and beta-adrenoceptor blocking agent for the treatment of various forms of hypertension, demonstrating efficacy comparable or superior to conventional antihypertensive therapies. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 8, 1983Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy

Labetalol: A Review of Its Pharmacology, Pharmacokinetics, Clinical Uses and Adverse Effects

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Why the study?

Is labetalol effective and safe for the treatment of hypertension and ischemic heart disease?

Population

Patients with hypertension and ischemic heart disease

Comparison

Labetalol (oral and intravenous) vs Placebo, diuretic therapy, conventional…

Design

Review

Authors

EME. Paul MacCarthyMerck & Co., Inc., Rahway, NJ, USA (United States)SBSaul S. BloomfieldUniversity of Cincinnati

Discussion

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Implication

Supports labetalol consideration in hypertension; extends beta-blocker evidence yet leaves open dedicated trials in ischemic heart disease.

Structured PICO

Is labetalol effective and safe for the treatment of hypertension and ischemic heart disease?

Population

Patients with hypertension (essential, renal, pheochromocytoma, pregnancy, emergencies) and ischemic heart disease

Intervention

Labetalol (oral and intravenous)

Comparator

Placebo, diuretic therapy, conventional beta-blockers, methyldopa, clonidine, and various adrenergic neuronal blockers

Outcome

Antihypertensive efficacy

Labetalol is a combined alpha- and beta-adrenoceptor blocker that is effective for various hypertensive conditions and emergencies.

Cite This Study

MacCarthy et al. (1983) studied this question.

synapsesocial.com/papers/6a1c08dcd54006be995f703f https://doi.org/10.1002/j.1875-9114.1983.tb03252.x

Topics

Hypertension management

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Implication

Supports labetalol consideration in hypertension; extends beta-blocker evidence yet leaves open dedicated trials in ischemic heart disease.

Labetalol: A Review of Its Pharmacology, Pharmacokinetics, Clinical Uses and Adverse Effects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Labetalol: A Review of Its Pharmacology, Pharmacokinetics, Clinical Uses and Adverse Effects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider