Key result
Dilated cardiomyopathy is linked to basal and equatorial LV dilatation rather than spherical remodeling.
Observational (n=43)
Absolute Event Rate: 63% vs 79.4%
p-value: p=<0.001
LV dilatation in cardiomyopathies is neither spherical nor proportional; challenges remodeling hypothesis and leaves open human validation.
AIMS: Some authors have hypothesized that left ventricular chamber dilatation in ischaemic and idiopathic cardiomyopathies results in spherical transformation. Aiming to characterize how this transformation occurs, a study was performed by comparing normal and dilated specimens regarding sphericity and proportionality in left heart chambers. It is important to provide data for the development of therapeutic strategies in these diseases. METHODS AND RESULTS: An anatomical study was performed by comparing normal (n = 10), ischaemic (n = 15), and idiopathic (n = 18) dilated human cardiomyopathic specimens regarding left ventricular chambers and their segmental proportionality to normal hearts. It was performed by capturing and processing images with proper software in three different levels of left ventricular chamber (basal, equatorial, and apical). These obtained data were analysed based on sphericity and proportionality by two dedicated indexes. Spherical shape: Calculated segmental indexes showed that dilated specimens were not spherical because they were smaller than as expected for a spherical shape (all values were <70% of a perfect sphere). Proportionality: There was no difference between basal index perimeters among groups, but apical index was lower in dilated specimens than in normal hearts, and so dilatation was not proportional to normal hearts. CONCLUSIONS: Left ventricular chambers of anatomical specimens with dilated cardiomyopathies did not display a spherical shape and were not proportional to normal hearts.
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Juliani et al. (2018) conducted an observational in Dilated cardiomyopathies (ischaemic and idiopathic) (n=43). Dilated cardiomyopathy (ischaemic and idiopathic) vs. Normal hearts was evaluated on Apical/Equatorial Intersegment Perimetral Index (IPI) (p=<0.001). Left ventricular chambers in dilated cardiomyopathies did not display a spherical shape and were not proportional to normal hearts, with dilatation being more accentuated in equatorial and basal regions.
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