Key result
Age >75 years (33.3% mortality), SBP <80 mmHg (60%), and NYHA IV (37.1%) were among several clinical and laboratory factors that significantly predicted inhospital mortality in elderly HF patients.
Why the study?
A range of factors predict mortality, morbidity, and outcome in CHF patients, but specific clinico-epidemiological characteristics and predictors of inhospital mortality in elderly patients warranted evaluation.
Observational
Clinical and laboratory parameters including advanced age, tachycardia, hypotension, severe NYHA class, anemia, renal dysfunction, hyponatremia, and reduced ejection fraction are significant predictors of inhospital mortality in elderly patients with heart failure.
May aid risk stratification in elderly HF inpatients; leaves open prospective validation before practice change.
Background: Heart failure (HF) is a complex clinical syndrome that results from any structural or functional impairment of ventricular filling or ejection of blood. There are range of factors that predict the mortality, morbidity, and outcome in congestive HF (CHF) patients. Objectives: The objective was to study the clinico-epidemiological characteristics and predictors of inhospital mortality of elderly patients ≥60 years hospitalized for HF. Subjects and Methods: A complete medical history of enrolled patients and physical examination inclusive of etiology, New York Heart Association (NYHA) grade, heart rate (HR), and systolic blood pressure (SBP) were noted. Complete blood count, blood urea, serum creatinine, serum sodium, serum potassium, 12-lead electrocardiogram, X-ray of the chest, and echo were obtained in all patients. Outcomes were analyzed till the study endpoints. Results: Compared to normal comparators, a higher mortality was observed in patients with age >75 years (33.3%), HR >100 beats per min (27.14%), SBP <80 mmHg (60%), NYHA IV HF (37.1%), hemoglobin (Hb) <12 mg/dl (31.25%), blood urea ≥40 mg/dl (26.39%), serum creatinine >1.30 mg/dl (29.17%), serum sodium <135 meq/L (26.69%), and ejection fraction (EF) <50% (26.39%). Conclusion: Increasing age, prior history of CHF on admission, higher NYHA grade on admission, higher HR, lower SBP, lower EF, low Hb, higher blood urea, serum creatinine, and low serum sodium levels are statistically significant predictors of inhospital mortality of elderly CHF patients.
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Sharda et al. (2023) conducted an observational in Congestive Heart Failure. Age >75 years (33.3% mortality), SBP <80 mmHg (60%), and NYHA IV (37.1%) were among several clinical and laboratory factors that significantly predicted inhospital mortality in elderly HF patients.
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