What does this research mean for the field?

Prostaglandins play a significant role in regulating peripheral blood flow and renal function in chronic heart failure, and the hemodynamic benefits of the ACE inhibitor captopril are partially mediated by increased prostaglandin synthesis. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1995HeartOpen Access

Peripheral haemodynamic effects of inhibition of prostaglandin synthesis in congestive heart failure and interactions with captopril.

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Why the study?

Does indomethacin alter central and peripheral hemodynamics and attenuate the effects of captopril in patients with chronic stable heart failure?

Structured PICO

Does indomethacin alter central and peripheral hemodynamics and attenuate the effects of captopril in patients with chronic stable heart failure?

Population

12 patients with chronic stable heart failure before starting treatment with angiotensin converting enzyme inhibitors.

Intervention

Oral indomethacin 50 mg followed by open intravenous infusion of prostaglandin E2 (study A) or oral indomethacin 50 mg given 30 min before open captopril (study B).

Comparator

Placebo followed by open intravenous infusion of prostaglandin E2 (study A) or placebo given 30 min before open captopril (study B).

Outcome

Changes in cardiac output, systemic vascular resistance, renal blood flow, glomerular filtration, urinary sodium excretion, and calf vascular resistance.surrogate

Prostaglandins play a significant role in regulating peripheral blood flow and renal function in stable chronic heart failure, and their inhibition by indomethacin attenuates the beneficial hemodynamic effects of captopril.

Discussion

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Implication

NSAIDs may blunt ACEI benefits in heart failure; confirms prostaglandins mediate captopril hemodynamics.

Cite This Study

Townend et al. (1995) studied this question.

synapsesocial.com/papers/6a1c0b4dd54006be995f72ae https://doi.org/10.1136/hrt.73.5.434

Topics

Heart failure HFrEF treatment

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Peripheral haemodynamic effects of inhibition of prostaglandin synthesis in congestive heart failure and interactions with captopril.

Structured PICO

Discussion

Implication

Cite This Study

Topics

Peripheral haemodynamic effects of inhibition of prostaglandin synthesis in congestive heart failure and interactions with captopril.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider