Key result
Greater genetic knowledge and higher education are linked to more positive attitudes toward pharmacogenetic testing.
Why the study?
Patient knowledge and attitudes toward pharmacogenetic (PGx) testing may impact adoption of clinical testing.
What are the attitudes and knowledge toward pharmacogenetic testing in patients undergoing CYP2C19 testing following percutaneous coronary intervention?
Cross-Sectional (n=308)
Yes
What are the attitudes and knowledge toward pharmacogenetic testing in patients undergoing CYP2C19 testing following percutaneous coronary intervention?
p-value: p=<0.001
Greater patient knowledge of genetics and higher education levels are associated with more positive attitudes toward pharmacogenetic testing after PCI, suggesting educational strategies may enhance clinical adoption.
Greater genetics knowledge and education were associated with positive PGx attitudes post-PCI; hypothesis-generating for educational strategies, should not yet change practice.
Aim: Patient knowledge and attitudes toward pharmacogenetic (PGx) testing may impact adoption of clinical testing. Methods: Questionnaires regarding knowledge, attitudes and ethics of PGx testing were distributed to 504 patients enrolled in the ADAPT study conducted at two urban hospitals in Philadelphia, Pennsylvania, USA. Responses were assessed using multivariable logistic regression. Results: 311 completed the survey (62% response rate). 74% were unaware of PGx testing, but 79% indicated using PGx results to predict medication efficacy was important. In a multivariable model, higher education level (p = 0.031) and greater genetics knowledge (p < 0.001) were associated with more positive attitudes toward PGx testing. Conclusion: Greater patient knowledge of genetics was associated with a more positive attitude toward PGx testing, indicating that educational strategies aimed at increasing genetics knowledge may enhance adoption of PGx testing in the clinic.
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Lee et al. (2022) conducted a cross-sectional in Patients undergoing percutaneous coronary intervention (n=308). Genetics knowledge and education level vs. Lower knowledge and education level was evaluated on Positive attitudes toward pharmacogenetic testing (p=<0.001). Greater patient knowledge of genetics (p < 0.001) and higher educational level (p = 0.031) were significantly associated with more positive attitudes toward pharmacogenetic testing.
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