Key result
Epigenetic modifications are linked to higher BP in children and adolescents in ~79% of studies.
Why the study?
The study aimed to discuss the potential role of epigenetics in hypertension among children and adolescents.
Are epigenetic modifications associated with hypertension in children and adolescents?
Systematic Review (n=14)
Are epigenetic modifications associated with hypertension in children and adolescents?
This systematic review suggests that epigenetic modifications are associated with higher blood pressure in children and adolescents, highlighting a potential mechanism for early-onset hypertension.
May support epigenetic research on pediatric hypertension risk; leaves open causal roles and clinical utility.
AIM: This systematic review study aimed to discuss about the possibility role of epigenetic in HTN of children and adolescent. MATERIAL AND METHODS: This evidence-based research is implemented within the scope of the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) 2020. The data were analyzed qualitatively to assess the risk of bias, with the New Ottawa Scale (NOS) and Agency for Health Research and Quality (AHRQ) criteria as the thresholds. Our research highlights in particular showed that there is a role for epigenetics in HTN in children and adolescents. CONCLUSION: Fourteen journals were included to be qualitatively assessed. Eleven journals (78.5%) stated that there was a correlation between epigenetic and BP in children and adolescents, however each study examined different genes or loci. In summary, epigenetic modifications of various single nucleotide polymorphisms (SNPs) and other genes were associated with higher systolic and diastolic BP in children and adolescents.
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Sukesi et al. (2025) conducted a systematic review in Hypertension (n=14). Epigenetic modifications was evaluated on Correlation between epigenetics and blood pressure. Epigenetic modifications of various single nucleotide polymorphisms and other genes were associated with higher systolic and diastolic blood pressure in children and adolescents in 78.5% of studies.
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