Key result
Epigenetic modifications are linked to elevated BP in Asian adults across ~93% of evaluated studies.
Why the study?
Elevated blood pressure is regulated by complex, poorly understood genetic and epigenetic pathways, and studies focused specifically on Asian adult populations have not been conducted.
Are epigenetic changes associated with hypertension in Asian adults?
Systematic Review (n=28)
Are epigenetic changes associated with hypertension in Asian adults?
Epigenetic modifications, including variations in SNPs and CPGs, appear to play a significant role in hypertension among Asian adults.
Epigenetic alterations at multiple loci associate with BP in Asian adults; extends prior GWAS to this ancestry and supports targeted research.
Background: Elevated high blood pressure is controlled by complicated, little-understood genetic and epigenetic pathways that are influenced by both heritable and environmental variables. Many adult systolic and diastolic blood pressure-related genomic loci have been identified through previous genome-wide association studies (GWAS); meanwhile, studies specifically on Asian adult populations have not been done. This study aims to comprehensively assess and summarize any gene changes that have been studied and see whether there is a possible influence between epigenetic changes and hypertension in Asian adults. Methods: This evidence-based analysis is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement and has been registered in PROSPERO under registration number [CRD42024622261]. The data were processed qualitatively to assess the risk of bias using the Newcastle-Ottawa Scale (NOS) and Agency for Health Research and Quality (AHRQ) standards as the threshold. Our study in particular shows that epigenetic modifications may play a role in hypertension, particularly in Asian individuals. Results: A total of 28 studies were selected for qualitative evaluation. In the adult Asian population, 26 publications (92.8%) reported a relationship between blood pressure and epigenetics. Every study describes a distinct gene or location associated with hypo- or hypermethylation. Elevated systolic and diastolic blood pressure was linked to variations of several single-nucleotide polymorphisms (SNPs), cytosine phosphate guanines (CPGs), and other monogenic genes. Conclusion: CRD42024622261.
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Sukesi et al. (2025) conducted a systematic review in Hypertension (n=28). Epigenetic changes was evaluated on Relationship between blood pressure and epigenetics. Epigenetic modifications were linked to elevated systolic and diastolic blood pressure in Asian adults in 26 of 28 evaluated studies (92.8%).
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