Key result
FDG PET/CT surpasses HRCT in diagnosing pulmonary lymphangitic carcinomatosis with up to ~97% sensitivity.
Why the study?
Pulmonary lymphangitic carcinomatosis is a rare, aggressive manifestation of metastatic cancer with poor prognosis, prompting an evaluation of [18F]FDG PET imaging in its assessment.
Does [18F]FDG PET/CT improve diagnostic and prognostic accuracy in patients with pulmonary lymphangitic carcinomatosis compared to HRCT?
Design
Comprehensive narrative review
Authors
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May support [18F]FDG PET/CT over HRCT for diagnosis; leaves open prospective validation and standardization.
Does [18F]FDG PET/CT improve diagnostic and prognostic accuracy in patients with pulmonary lymphangitic carcinomatosis compared to HRCT?
[18F]FDG PET/CT demonstrates high diagnostic accuracy and prognostic value for pulmonary lymphangitic carcinomatosis, though standardization is needed for broader clinical integration.
Dondi et al. (2025) conducted a review in Pulmonary lymphangitic carcinomatosis (PLC). [18F]FDG PET/CT imaging vs. High-resolution computed tomography (HRCT) was evaluated on Diagnostic accuracy (sensitivity and specificity). [18F]FDG PET/CT imaging demonstrates high diagnostic accuracy for pulmonary lymphangitic carcinomatosis, with sensitivity of 86-97% and specificity of 84-100%, surpassing HRCT.
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