Key result
In a computer model of a fibrillating cardiac tissue sheet, uniform anisotropy contributed less significantly to wavelet fractionation than overall velocity changes.
Computer modeling suggests that overall velocity changes play a more significant role in wavelet fractionation during fibrillation than uniform anisotropy.
No immediate clinical implications for arrhythmia management; leaves open whether conduction velocity dominates anisotropy in human wavelet fractionation.
Using a 10000-element modified Moe computer model of a fibrillating cardiac tissue sheet, cases of isotropic and uniformly anisotropic conduction were implemented and compared to determine how uniform anisotropy contributes to wavelet fractionation. In this model, a bipolar electrogram calculation based on the Ploney volume-conductor equations is implemented in several simple test cases and in a fibrillating, isotropic model sheet. It is shown that in this computer model, the role of uniform anisotropy in wavelet fractionation is less significant than effects due to overall velocity changes. Bipolar recordings in this model can approximate many characteristics in both the time and frequency domains of fibrillation cardiac tissue.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
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Sih et al. (2002) studied Fibrillation. Uniformly anisotropic conduction vs. Isotropic conduction was evaluated on Wavelet fractionation. In a computer model of a fibrillating cardiac tissue sheet, uniform anisotropy contributed less significantly to wavelet fractionation than overall velocity changes.
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