Key result
In a computer model of atrial fibrillation, introducing anisotropy (>3:1 ratio) increased highly asymmetric electrograms to 12-15%, compared to <2% in homogeneous tissue.
Population
Computer model of entire human atria with gross fiber architecture based on histology and membrane kinetics…
Comparison
Simulated paced activation and simulated AF with… vs Homogeneous and isotropic tissue model
Design
Preclinical
Authors
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Hypothesis-generating that anisotropy drives electrogram asymmetry in AF; extends computational models but leaves clinical translation open.
Computer modeling demonstrates that variations in unipolar atrial electrogram morphology, such as asymmetry and fractionation, reflect underlying tissue anisotropy and conductivity changes during atrial fibrillation.
Jacquemet et al. (2003) studied Atrial fibrillation. Computer model of human atria with anisotropy and conductivity changes vs. Homogeneous and isotropic tissue model was evaluated on Unipolar electrogram morphology (amplitude, symmetry, and fractionation). In a computer model of atrial fibrillation, introducing anisotropy (>3:1 ratio) increased highly asymmetric electrograms to 12-15%, compared to <2% in homogeneous tissue.
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