Key result
Field stimulation applied to non-uniform, decoupled cardiac tissue resulted in more virtual electrodes and successfully terminated spiral waves, unlike in uniform, homogeneous tissue.
Computer simulations suggest that the success of defibrillation (termination of spiral waves) is facilitated by intracellular decoupling and spatial heterogeneity in cardiac tissue.
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Simulations suggest virtual electrodes enable defibrillation in decoupled tissue; leaves open experimental validation before clinical translation.
Kuijpers et al. (2005) studied Cardiac tissue (normal, decoupled, and non-uniform). Field stimulation vs. Uniform, homogeneous tissue was evaluated on Termination of spiral waves and virtual electrode polarization. Field stimulation applied to non-uniform, decoupled cardiac tissue resulted in more virtual electrodes and successfully terminated spiral waves, unlike in uniform, homogeneous tissue.
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