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October 14, 2004Cardiovascular Research

The fine-scale architecture of defibrillation

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Key result

High-resolution optical mapping of transmural polarization during defibrillation revealed both positive and negative virtual electrode polarizations, validating the virtual electrode theory.

Design

Editorial

Authors

AHA.V. HoldenUniversity of Leeds

Discussion

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Overview

Extends validation of virtual electrode theory; hypothesis-generating for defibrillation optimization, without immediate clinical translation.

PICO

P
Population
Ventricular fibrillation
I
Intervention / Comparator
Defibrillation

This editorial highlights the importance of high-resolution optical mapping in validating virtual electrode theory for understanding the intramural effects of defibrillating shocks.

Limitations

  • Optical recording methods (voltage-sensitive dyes and excitation-contraction uncouplers) introduce artifacts since membrane channel kinetics and cell-to-cell coupling can be altered.

Cite This Study

A.V. Holden (2004) conducted an editorial in Ventricular fibrillation. Defibrillation was evaluated. High-resolution optical mapping of transmural polarization during defibrillation revealed both positive and negative virtual electrode polarizations, validating the virtual electrode theory.

synapsesocial.com/papers/6a9404d401d6912b871d4e6chttps://doi.org/10.1016/j.cardiores.2004.09.015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Periodic Conductivity as a Mechanism for Cardiac Stimulation and Defibrillation1987 · 116 citations
  2. 2A Tale of Two Fibrillations2003 · 116 citations
  3. 3What do implantable cardioverter/defibrillators teach us about the mechanisms of sudden cardiac death?2001 · 15 citations
  4. 4Defibrillation and cardioversion2002 · 32 citations
  5. 5Choosing the Optimal Monophasic and Biphasic Waveforms for Ventricular Defibrillation1995 · 105 citations