Mechanisms of Intracellular Protein Breakdown

A Hershko; Aaron Ciechanover

doi:10.1146/annurev.bi.51.070182.002003

June 1, 1982Annual Review of Biochemistry

Mechanisms of Intracellular Protein Breakdown

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Key Points

To review the evolutionary conservation, signaling mechanisms, and biological functions of the Hippo signaling pathway in regulating tissue growth and cell fate.
Examined foundational genetic signaling literature established in Drosophila melanogaster models.
Synthesized molecular mechanisms governing downstream biochemical cascades, tissue development, and intracellular protein turnover.
The Hippo pathway operates as a key evolutionarily conserved cascade that sets boundaries for organ size across animal species.
Downstream signaling outputs directly control fundamental biological processes, specifically cell proliferation, survival, and cell fate decisions.

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Implication

Review uncovers conserved Hippo signaling cascade functions in cellular models, highlighting critical mechanisms governing tissue growth and organ size.

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Hershko et al. (1982) studied this question.

synapsesocial.com/papers/6a1c1da60a1f7575939d8808 https://doi.org/10.1146/annurev.bi.51.070182.002003

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Mechanisms of Intracellular Protein Breakdown

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Mechanisms of Intracellular Protein Breakdown

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