What does this research mean for the field?

Sublingual nitrendipine, sublingual nifedipine, and intravenous clonidine show similar efficacy in rapidly reducing blood pressure during hypertensive urgencies and emergencies, but nitrendipine is better tolerated with fewer side effects. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1988Journal of Cardiovascular PharmacologyOpen Access

Treatment of Hypertensive Urgencies and Emergencies with Nitrendipine, Nifedipine, and Clonidine

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Why the study?

Does sublingual nitrendipine safely and effectively reduce blood pressure compared to nifedipine and clonidine in patients with hypertensive urgencies and emergencies?

Population

45 patients with hypertensive urgencies and emergencies

Comparison

Nitrendipine 5 mg given sublingually via a phiole vs Nifedipine 20 mg given sublingually via two…

Design

RCT, randomized

Follow-up

8 hours

Authors

FSF. SpähHelios Klinikum Krefeld KGK. D. GrosserHelios Klinikum Erfurt

Discussion

Member takes

Implication

Sublingual nitrendipine may be preferred for hypertensive urgencies due to better tolerability; extends RCT evidence for dihydropyridines beyond nifedipine.

Structured PICO

Does sublingual nitrendipine safely and effectively reduce blood pressure compared to nifedipine and clonidine in patients with hypertensive urgencies and emergencies?

Population

45 patients with hypertensive urgencies and emergencies

Intervention

Nitrendipine 5 mg given sublingually via a phiole

Comparator

Nifedipine 20 mg given sublingually via two pierced 10-mg capsules, or Clonidine 0.15 mg given intravenously

Outcome

Blood pressure and heart rate changes within 60 minutes and up to 8 hours after intakesurrogate

Sublingual nitrendipine is as effective as nifedipine and clonidine for treating hypertensive urgencies and emergencies, but is better tolerated without causing reflex tachycardia.

Cite This Study

Späh et al. (1988) studied this question.

synapsesocial.com/papers/6a1c1fc4ea84844e355f7ab1 https://doi.org/10.1097/00005344-198806124-00035

Topics

Hypertension management

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Implication

Sublingual nitrendipine may be preferred for hypertensive urgencies due to better tolerability; extends RCT evidence for dihydropyridines beyond nifedipine.

Treatment of Hypertensive Urgencies and Emergencies with Nitrendipine, Nifedipine, and Clonidine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Treatment of Hypertensive Urgencies and Emergencies with Nitrendipine, Nifedipine, and Clonidine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider