What does this research mean for the field?

Mammalian skeletal muscle C-protein is a ~50 nm rod-like structure that binds directly to titin and myosin rods, and its full-length human sequence reveals highly conserved fibronectin-like domains and significant homology with avian C-protein. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1992Journal of Cell Science

Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA

View Full Paper

Ask AI

Bookmark

Population

Bovine skeletal muscle and fetal human skeletal muscle cDNA library

Design

Preclinical

Authors

DFDieter O. FürstHeart Failure & Transplant UVUwe VinkemeierUniversity of Nottingham KWKlaus WeberUniversity of Geneva

Discussion

Member takes

Implication

Hypothesis-generating for sarcomere mechanics; leaves open therapeutic roles in human myopathies.

Structured PICO

Population

Bovine skeletal muscle and fetal human skeletal muscle cDNA library

Intervention

Purification of C-protein, binding assays to titin and myosin, and cDNA sequencing

Outcome

Characterization of C-protein structure, binding properties, and full-length human cDNA sequence

The study provides a fast purification method for mammalian skeletal muscle C-protein and characterizes its human cDNA sequence, revealing structural domains and binding properties to titin and myosin.

Cite This Study

Fürst et al. (1992) studied this question.

synapsesocial.com/papers/6a1c212cd54006be995f987b https://doi.org/10.1242/jcs.102.4.769

View Full Paper

Ask AI

Bookmark

August 1, 1992Journal of Cell Science

Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA

View Full Paper

Ask AI

Bookmark

Population

Bovine skeletal muscle and fetal human skeletal muscle cDNA library

Design

Preclinical

Authors

DFDieter O. FürstHeart Failure & Transplant UVUwe VinkemeierUniversity of Nottingham KWKlaus WeberUniversity of Geneva

Discussion

Member takes

Implication

Hypothesis-generating for sarcomere mechanics; leaves open therapeutic roles in human myopathies.

Structured PICO

Population

Bovine skeletal muscle and fetal human skeletal muscle cDNA library

Intervention

Purification of C-protein, binding assays to titin and myosin, and cDNA sequencing

Outcome

Characterization of C-protein structure, binding properties, and full-length human cDNA sequence

Cite This Study

Fürst et al. (1992) studied this question.

synapsesocial.com/papers/6a1c212cd54006be995f987b https://doi.org/10.1242/jcs.102.4.769

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark