Localization of C-protein isoforms in chicken skeletal muscle: ultrastructural detection using monoclonal antibodies.

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Population

Chicken skeletal muscle myofibers from three muscle types

Design

Preclinical

Authors

Discussion

Co-localization in chicken skeletal muscle leaves open relevance to human cardiac thick filaments; mammalian studies needed.

Population

Chicken skeletal muscle myofibers from three muscle types

Intervention

Ultrastructural detection using monoclonal antibodies specific for fast (MF-1) and slow (ALD-66) isoforms of C-protein

Outcome

Ultrastructural localization and distribution of C-protein isoforms in the A-bandsurrogate

Demonstrates that fast and slow isoforms of C-protein can co-localize at binding sites 43 nm apart along thick filaments in chicken skeletal muscle.

Dennis et al. (1984) studied this question.

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