Key result
Hypertension is linked to ~27% higher odds of interatrial block, independent of obesity.
Why the study?
The study was conducted to characterise the independent associations of obesity and hypertension with interatrial block after adjusting for cardiovascular risk factors, echocardiographic LAD, and LVMI in a large general Chinese population.
Are hypertension and overweight/obesity independently associated with interatrial block in a general Chinese population?
Cross-Sectional (n=11,264)
Yes
Are hypertension and overweight/obesity independently associated with interatrial block in a general Chinese population?
Hypertension and overweight/obesity are independently associated with interatrial block in the general Chinese population, independent of left atrial diameter and left ventricular mass index.
Hypertension and obesity were associated with interatrial block; hypothesis-generating for atrial conduction risk in general populations and requires prospective confirmation.
Objectives This current study was performed to characterise the independent associations of obesity and hypertension with interatrial block (IAB) after adjusting for cardiovascular risk factors, echocardiographic left atrial diameter (LAD) and left ventricular mass index (LVMI) in a large general Chinese population. Design A cross-sectional study. Setting and participants A total of 11 956 permanent residents (≥35 years of age) from Liaoning Province in China were included in this study. Following the completion of a questionnaire, the enrolled participants were subjected to physical examinations, laboratory analyses, ECG and echocardiogram. Linear and logistic regression analyses were performed to evaluate the associations of hypertension and obesity with IAB. Outcome measures IAB was defined as a prolongation of the P wave duration ≥120 ms on a digital 12-lead ECG. Results The prevalence of IAB in hypertensive individuals was higher than the normotensive in both men (9.5 vs 5.9%; p<0.001) and women (6.6 vs 3.6%; p<0.001). In addition, the prevalence of IAB exhibited a sharp increase with advancing body mass index (BMI) in both men (from 4.9% to 13.0%) and women (from 3.5% to 6.9%) (ps- for trend <0.001). Multiple relevant clinical covariates, echocardiographic LAD and LVMI were adjusted in the multivariate linear and logistic regression analyses. The results revealed that systolic blood pressure, diastolic blood pressure and BMI were all independently associated with P wave duration (β=0.02, 0.09 and 0.25, respectively; all ps <0.005). Furthermore, hypertension was found to be independently associated with IAB (OR=1.27; p=0.018), while both overweight and obesity exhibited higher odds of IAB (OR=1.42 and 1.67, respectively; ps <0.005), compared with BMI <24.0 kg/m 2 . Conclusions The key findings of this study highlighted that hypertension and overweight/obesity were independently and significantly associated with IAB in general Chinese population.
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Sun et al. (2019) conducted a cross-sectional in Interatrial block (n=11,264). Hypertension and obesity vs. Normotension and normal BMI (<24.0 kg/m2) was evaluated on Interatrial block (prolonged P wave duration ≥120 ms) (OR 1.27, p=0.018). Hypertension and obesity were independently associated with higher odds of interatrial block (OR 1.27 and 1.67, respectively) after adjusting for cardiovascular risk factors and echocardiographic changes.
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