Key result
Vitamin D3 supplementation (2,000 U/day) for 5 months in a patient with vitamin D deficiency reduced premature ventricular contraction burden from 25,500 to 119 per 24 hours.
Why the study?
High PVC burden can cause symptoms, driving the search for treatments that decrease burden without the side effects of antiarrhythmic drugs or catheter ablation.
Does vitamin D3 supplementation reduce PVC burden in a patient with frequent premature ventricular contractions and vitamin D deficiency?
Case Report (n=1)
No
Does vitamin D3 supplementation reduce PVC burden in a patient with frequent premature ventricular contractions and vitamin D deficiency?
Vitamin D supplementation significantly reduced high-burden PVCs in a patient with vitamin D deficiency, avoiding the need for antiarrhythmic drugs or catheter ablation.
A high premature ventricular contractions (PVC) burden can disturb the patient’s condition through fatigue during exercise or palpitations. Hence, researchers started to look for treatment options that decrease PVC burden without the side effects of antiarrhythmic drugs, and vitamin D could be a valuable solution and safe alternative to drugs or catheter ablation for high-burden PVCs. We present the case of a 24-year-old patient with high-burden PVC of >25,500/24 hours referred for urgent catheter ablation. Treatment with beta-blockers and calcium blockers did not reduce PVC burden. Under propafenone, there was a slight reduction in the number of PVCs to 21,200/24 hours, therefore the patient was referred for catheter ablation. As there was a vitamin D deficiency of 10.1 ng/mL, an attempt of vitamin D supplementation was done, with increase of vitamin D to 32.1 ng/mL and decrease of PVC burden to 9,600/24 hours. Further dietary supplementation increased 25-OH vitamin D to 50.2 ng/mL and decreased the PVC burden to 119/24 hours. Consequently, catheter ablation was canceled, and the patient remained free of antiarrhythmic drugs.
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Cismaru et al. (2021) conducted a case report in Frequent Premature Ventricular Contractions (n=1). Vitamin D3 supplementation vs. Baseline was evaluated on Premature ventricular contraction (PVC) burden per 24 hours (99% relative reduction). Vitamin D3 supplementation (2,000 U/day) for 5 months in a patient with vitamin D deficiency reduced premature ventricular contraction burden from 25,500 to 119 per 24 hours.
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