Subendocardial quantification enhances coronary artery disease detection in 18F-flurpiridaz PET

Figures

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  Fig. 1. Study overview. MPI– myocardial perfusion imaging; Quant– quantitative analysis; PET– positron emission tomography; Sen– sensitivity; Spe– specificity, Subendo - subendocardial

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  Fig. 2. Total perfusion deficit for ≥ 50% stenosis for all participants. The diagnostic performance and Sensitivity (Sen) and Specificity (Spe) of transmural and subendocardial (subendo) stress (A) and ischemic (B) total perfusion deficit (TPD) for coronary artery disease defined as ≥ 50% stenosis is compared with expert readers’ summed stress and summed difference scores. 326 subjects were positive by invasive angiography. Only significant p-values (< 0.05) are presented in the figure. Red asterisk: p < 0.05 for readers versus subendocardial TPD. Black asterisk: p < 0.05 for readers versus transmural TPD. AUC– area under the receiver operating characteristic curve; CI– confidence interval

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  Fig. 3. Case example. Automatic quantification of transmural and subendocardial perfusion in a 65-year-old male patient with coronary artery disease, identified by invasive angiography as having 57% stenosis in the left anterior descending artery. The top panel shows perfusion images in the vertical long axis under stress (left), at rest (middle), and the difference between stress and rest (right). Transmural perfusion quantification indicated a stress total perfusion deficit (TPD) of 3% and ischemic TPD of 3% whereas subendocardial quantification indicated a stress TPD of 16% and ischemic TPD of 10%. The three readers’ (R1, R2, R3) summed stress scores (SSS) and summed difference scores (SDS) were considered to be normal