First Post-Approval Clinical Use of F-18 Flurpiridaz With Exercise Cardiac PET in the United States

Figures

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  Visual Summary. F-18 Flurpiridaz Allows for Integration of Exercise Stress With Cardiac PET

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  Figure 1. Exercise Cardiac PET/CT Protocol Resting cardiac positron emission tomography (PET)/computed tomography (CT) imaging was performed after injection of 3.1 mCi of F-18 flurpiridaz for 15 minutes, which included acquisition of dynamic rest data. Approximately 60 minutes after the rest radiotracer injection, the patient exercised for 10 minutes on the Bruce treadmill protocol and was injected with 8 mCi of F-18 flurpiridaz at peak exercise. Exercise stress myocardial perfusion imaging with gated PET/CT was performed 15 minutes later for a duration of 10 minutes. CTAC = Computed Tomography Attenuation Correction.

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  Figure 2. Exercise Cardiac PET Myocardial Perfusion Imaging Findings Abnormal positron emission tomography (PET) myocardial perfusion imaging showing perfusion defects in the left anterior descending and right coronary artery territories, including (A) a large area of mild ischemia in the apical to basal anterior wall, apical septum, and true left ventricular apex (red arrows) and (B) a medium-sized area of mild ischemia in the apical to basal inferior and mid-inferoseptal walls (white arrows).