Variation of diastolic time fraction demonstrated it is a significant determinant of subendocardial perfusion, with systolic compression exerting a flow-limiting effect into diastole (P<0.001).
Diastolic time fraction is a key determinant of subendocardial perfusion, with systolic compression exerting a flow-limiting effect into diastole.
p-value: p=<0.001
Diastolic time fraction (DTF) has been recognized as an important determinant for subendocardial perfusion, but microsphere studies in which DTF was the independent variable are practically absent. In 21 anesthetized goats, the left coronary main stem was artificially perfused at controlled pressure. DTF was varied by pacing the heart, vagus stimulation, or administration of dobutamine. Regional coronary flow was measured with fluorescent microspheres under full adenosine dilation. Perfusion pressure (P(c)) was defined as mean coronary arterial pressure minus minimal left ventricular pressure. Regional flow conductances (flow/P(c)) were as follows: for the subendocardium, C(endo) = -0.103 + 0.197 DTF + 0.00074 P(c) (P 80 beats/min.
Fokkema et al. (Thu,) reported a other. Variation of Diastolic time fraction (DTF) was evaluated on Regional coronary flow conductance (p=<0.001). Variation of diastolic time fraction demonstrated it is a significant determinant of subendocardial perfusion, with systolic compression exerting a flow-limiting effect into diastole (P<0.001).
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