Key result
Modulation of coronary sinus or left ventricular intracavity pressure demonstrated a direct linear relation (r2 = 0.59, P = 0.001) between measured and calculated diastolic subendocardial tissue pressure and coronary pressure at zero-flow.
Population
Anesthetized, instrumented dogs
Design
Preclinical
Authors
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May influence coronary pressure-flow interpretation in patients; leaves open translation from canine models.
Effect estimate: r2 = 0.59
p-value: p=0.001
The study demonstrates a direct linear relationship between measured and calculated diastolic subendocardial tissue pressure and coronary pressure at zero-flow, validating the use of calculated back pressure for evaluating myocardial perfusion.
Rouleau et al. (2017) studied Healthy (anesthetized dogs) (n=19). Modulation of coronary sinus or left ventricular intracavity pressure vs. Baseline conditions was evaluated on Correlation between measured and calculated diastolic subendocardial tissue pressure and coronary pressure at zero flow (r2 = 0.59, p=0.001). Modulation of coronary sinus or left ventricular intracavity pressure demonstrated a direct linear relation (r2 = 0.59, P = 0.001) between measured and calculated diastolic subendocardial tissue pressure and coronary pressure at zero-flow.
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