Synergistic inhibition of platelet activation by plasmin and prostaglandin I2
Population
Washed platelets and platelet-rich plasma (in vitro model)
Comparison
Prostacyclin combined with plasmin vs PGI2 alone or plasmin alone
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Does not change practice; hypothesis-generating for PGI2-plasmin synergy in human hemostasis.
Structured PICO
P
Population
Washed platelets and platelet-rich plasma (in vitro model)
I
Intervention
Prostacyclin (PGI2) combined with plasmin (or tissue plasminogen activator)
C
Comparator
PGI2 alone or plasmin alone
O
Outcome
Thrombin- and ADP-induced platelet aggregationsurrogate
Prostacyclin and plasmin synergistically inhibit platelet activation through both cyclic AMP-dependent and independent mechanisms, which may play a role in localizing hemostatic plugs to sites of vascular injury.
Cite This Study
Schafer et al. (1987) studied this question.